Medical Research Updates ⌠MRU⌡. ORIGINAL RESEARCH ARTICLE
MRU 2024; Vol.1(Issue2): 19-24 ISSN 200XX |
DOI: https://www.mruj.online/_downloads/c4d0aa9d3b9526980434be67dff8a1a8
MLH1 and MSH2 gene mutation patterns in Lynch syndrome-associated colorectal
cancer in Sudan
Balgis Elhag Ibrahim Tager1, Salah Eldin G. Elzaki2, and Ahmed Abdula Agabeldour 3
1Department of Histopathology and Cytology, Faculty of Medical Laboratory
Sciences, West Kordofan University, Elnuhood, Sudan.
2Department of molecular epidemiology, Tropical Medicine Research
Institute, National Centre for Research Khartoum Sudan.
3Department of Pathology, Faculty of Medicine, Kordofan University, El-Obeid,
Sudan.
ABSTRACT
Background: Colorectal cancer (CRC) is increasingly becoming dominant in Sudan, which is
attributed to several factors, including hereditary mutations in the DNA mismatch repair
genes MLH1 and MSH2. Therefore, this study aimed to examine the MLH1 and MSH2 gene
mutation patterns in Lynch syndrome-associated colorectal cancer in a series of Sudanese
patients with CRC. Methodology: This study investigated 50 patients with CRC who attended
El-Obeid Hospital during the period from 2017 to 2022. The presence of MLH1 and MSH2
was indicated by immunohistochemical testing of formalin-fixed, paraffin-wax-embedded
tissues. Results: The MLH1 mutation was positive in 28% of the study population and
negative in 72% of them. The MSH2 mutation was positive in 42% and negative in 58% of the
study subjects. The MLH1 and MSH2 mutations shared positivity in 18% and negativity in
24% of the cases. Conclusion: According to the present studies, CRC is more prevalent in
women. LS is more common in Sudanese patients with CRC than in many other reports
throughout the world. MSH2 mutations are more prevalent in Sudanese patients than MLH1
mutations.
Keywords: colorectal cancer, Lynch syndrome, MLH1, MSH2, Sudan.
Correspondence to: Balgis Elhag Ibrahim Tager, Email: bintelhag@yahoo.com
Cite this article: Tager BEI, Elzaki SGE2, and Agabeldour AA. Medical Research
Updates 2024;1(2):1-5. DOI:
https://www.mruj.online/_downloads/c4d0aa9d3b9526980434be67dff8a1a8
